Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus.

Abstract

OBJECTIVE To study 5 type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) in patients with systemic lupus erythematosus (SLE) and to correlate expression levels with disease activity and/or clinical manifestations. METHODS Peripheral blood cells were obtained from 48 SLE patients, 48 normal controls, and 22 rheumatic disease controls… (More)

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