Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis.

@article{Laberge1998AssociationOI,
  title={Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis.},
  author={Sophie S Laberge and Omar Ghaffar and Mark Boguniewicz and David M. Center and Donald Y M Leung and Qutayba A Hamid},
  journal={The Journal of allergy and clinical immunology},
  year={1998},
  volume={102 4 Pt 1},
  pages={
          645-50
        }
}
BACKGROUND The mechanisms involved in the initiation and the maintenance of skin inflammation in atopic dermatitis (AD) are poorly understood. Previous studies have demonstrated increased numbers of infiltrating CD4+ T cells in acute lesions compared with normal control skin. IL-16 is a cytokine that has selective chemotactic activity for CD4+ cells. OBJECTIVE We sought to examine whether IL-16 expression might be upregulated in acute versus chronic AD. METHODS We investigated the… CONTINUE READING
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