Association of incident cardiovascular disease with periodic limb movements during sleep in older men: outcomes of sleep disorders in older men (MrOS) study.

@article{Koo2011AssociationOI,
  title={Association of incident cardiovascular disease with periodic limb movements during sleep in older men: outcomes of sleep disorders in older men (MrOS) study.},
  author={Brian B. Koo and Terri L. Blackwell and Sonia Ancoli-Israel and Katie L. Stone and Marcia L. Stefanick and Susan Redline},
  journal={Circulation},
  year={2011},
  volume={124 11},
  pages={1223-31}
}
BACKGROUND Periodic limb movements during sleep (PLMS) cause repetitive sympathetic activation and may be associated with increased cardiovascular risk. We hypothesized that PLMS frequency (periodic limb movement index [PLMI]) and PLMS arousal frequency (periodic limb movement arousal index [PLMAI]) are predictive of incident cardiovascular disease, including coronary heart disease, peripheral arterial disease, and cerebrovascular disease, in an elderly male cohort. METHODS AND RESULTS A… CONTINUE READING
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