Association of immunoescape mechanisms with Epstein-Barr virus infection in nasopharyngeal carcinoma.

@article{Ogino2007AssociationOI,
  title={Association of immunoescape mechanisms with Epstein-Barr virus infection in nasopharyngeal carcinoma.},
  author={Takeshi Ogino and Shigetaka Moriai and Yoshiya Ishida and Hideyuki Ishii and Akihiro Katayama and Naoyuki Miyokawa and Yasuaki Harabuchi and Soldano Ferrone},
  journal={International journal of cancer},
  year={2007},
  volume={120 11},
  pages={2401-10}
}
We have investigated the association of immunoescape mechanisms in nasopharyngeal carcinoma (NPC) lesions with Epstein-Barr virus (EBV) infection and clinical course of the disease. Tumor biopsy specimens obtained from 36 Japanese NPC patients were examined for antigen processing machinery component and HLA class I antigen expression, CD8(+) T cell infiltration, and Fas, Fas ligand (FasL) and IL-10 expression using immunohistochemical staining. The results were correlated with the… CONTINUE READING