Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population.

@article{Wipff2009AssociationOH,
  title={Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population.},
  author={Julien Wipff and Philippe Dieud{\'e} and J{\'e}r{\^o}me Avouac and Kiet Phuong Tiev and {\'E}ric Hachulla and Brigitte Granel and Elisabeth Diot and Jean Sibilia and Luc Mouthon and Olivier Meyer and Andr{\'e} Kahan and Catherine Boileau and Yannick Allanore},
  journal={Scandinavian journal of rheumatology},
  year={2009},
  volume={38 4},
  pages={291-4}
}
OBJECTIVE Systemic sclerosis (SSc) is a connective tissue disease characterized by generalized microangiopathy leading to chronic hypoxia. The aim of this study was to determine whether polymorphisms of the hypoxia-inducible factor 1A gene (HIF1A) affects susceptibility to SSc in a large French European Caucasian population. METHODS A case-control study was performed in 659 SSc patients and 511 healthy matched controls. Three tag single nucleotide polymorphisms (SNPs) of the HIF1A gene… CONTINUE READING
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