Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.

@article{Zarychanski2013AssociationOH,
  title={Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.},
  author={Ryan Zarychanski and Ahmed M. Abou-Setta and Alexis F Turgeon and Brett L Houston and Lauralyn McIntyre and John C Marshall and Dean Fergusson},
  journal={JAMA},
  year={2013},
  volume={309 7},
  pages={678-88}
}
IMPORTANCE Hydroxyethyl starch is commonly used for volume resuscitation yet has been associated with serious adverse events, including acute kidney injury and death. Clinical trials of hydroxyethyl starch are conflicting. Moreover, multiple trials from one investigator have been retracted because of scientific misconduct. OBJECTIVES To evaluate the association of hydroxyethyl starch use with mortality and acute kidney injury. DATA SOURCES Randomized controlled trials from MEDLINE, EMBASE… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 195 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

The influence of volume therapy and pentoxifylline infusion on circulating adhesion mol SERIOUS ADVERSE EVENTS AND HYDROXYETHYL STARCH ©2013 American Medical Association

  • J Boldt, M Heesen, W Padberg, K Martin, G. Hempelmann
  • All rights reserved. JAMA, February 20,
  • 2013

BaSES Trial: Basel Starch Evaluation in Sepsis. ClinicalTrials.gov 2012; http: //clinicaltrials.gov/ct2/show/study/NCT00273728

  • M. Siegemund
  • Accessed October
  • 2012
1 Excerpt

Similar Papers

Loading similar papers…