Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects.

  title={Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects.},
  author={Beatriz de Brito Bezerra and Mariana Amade Mendes Braz{\~a}o and Mirella Lindoso Gomes de Campos and M{\'a}rcio Zaffalon Casati and En{\'i}lson Ant{\^o}nio Sallum and Ant{\^o}nio Wilson Sallum},
  journal={Clinical oral implants research},
  volume={23 8},
OBJECTIVES To evaluate the effects of a 1% hyaluronic acid (HA) gel in combination with an absorbable collagen sponge (ACS) in the healing of critical-size calvaria defects in rats. MATERIAL AND METHODS Thirty-two adult Wistar rats were used. Two 5-mm-diameter critical-size defects were created and the treatments were randomly distributed as follows: (1) 1% HA; (2) 1% HA gel-soaked ACS; (3) control (blood clot); and (4) ACS. The animals were sacrificed 60 days post-surgery, when biopsies were… CONTINUE READING


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