Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer.

@article{Vernon1997AssociationOH,
  title={Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer.},
  author={Suzanne D. Vernon and Elizabeth R. Unger and Daniel L. Miller and Daisy R. Lee and William C. Reeves},
  journal={International journal of cancer},
  year={1997},
  volume={74 1},
  pages={50-6}
}
To determine the clinical relevance of human papillomavirus (HPV) integration and E2 function suggested by in vitro studies, we investigated 50 patients with HPV 16-positive primary cervical carcinoma (stage Ib-IV) diagnosed and treated at one institution. The physical state of HPV was determined by colorimetric in situ hybridization and was not found to vary by stage. Overall, 62% of tumors had integrated HPV, 16% had episomal and 22% had both integrated and episomal. The E1/E2 region was… CONTINUE READING

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