Association of human papillomavirus type 11 DNA with squamous cell carcinoma of the tongue.

@article{Fife1996AssociationOH,
  title={Association of human papillomavirus type 11 DNA with squamous cell carcinoma of the tongue.},
  author={Kenneth H. Fife and Li Fan and Michael H Fritsch and Jenny Bryan and Darron R. Brown},
  journal={Archives of otolaryngology--head & neck surgery},
  year={1996},
  volume={122 12},
  pages={1404-8}
}
A 47-year-old man with a history of a benign papilloma of the tongue 5 years earlier was treated for a squamous cell carcinoma of the tongue with surgical resection. An analysis of the tumor DNA using several methods showed the presence of human papillomavirus (HPV) type 11 sequences that migrated with the high molecular weight cellular DNA, suggesting integration of viral DNA into the cellular genome. A segment of the HPV DNA was cloned from the lesion and shown to be similar to prototype HPV… CONTINUE READING