Association of human papillomavirus L1 capsid protein with koilocytosis, expression of p16, and Ki-67, and its potential as a prognostic marker for cervical intraepithelial neoplasia.

@article{Chen2013AssociationOH,
  title={Association of human papillomavirus L1 capsid protein with koilocytosis, expression of p16, and Ki-67, and its potential as a prognostic marker for cervical intraepithelial neoplasia.},
  author={Lan Chen and Ming-jun Sun and Hong-yan Shi and Qing He and Dong-ge Liu},
  journal={Analytical and quantitative cytopathology and histopathology},
  year={2013},
  volume={35 3},
  pages={139-45}
}
OBJECTIVE To study the relationship between human papillomavirus (HPV) L1 capsid protein (L1) and koilocytosis on ThinPrep cytology tests (TCTs) and the association of HPV L1 with p16 and Ki-67 expression in their corresponding biopsies. STUDY DESIGN TCTs of 75 patients with high-risk HPV infection were studied for cytologic features of koilocytosis and for HPV L1 expression using combined detection of in situ hybridization and immunocytochemistry. All TCTs had follow-up biopsies on which p16… CONTINUE READING