Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

@article{Soldan1997AssociationOH,
  title={Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA},
  author={Samantha S. Soldan and Rossana Berti and Nazi Salem and Paola Secchiero and Louis Flamand and Peter A. Calabresi and Meghan B. Brennan and Heidi Wynn Maloni and Henry F. McFarland and Hun-Chi Lin and Madhumita Patnaik and Steven Jacobson},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={1394-1397}
}
Viruses have long been suggested to be involved in the etiology of multiple sclerosis (MS)1. This suggestion is based on (1) epidemiological evidence of childhood exposure to infectious agents and increase in disease exacerbations with viral infection1,2; (2) geographic association of disease susceptibility with evidence of MS clustering3–4; (3) evidence that migration to and from high-risk areas influences the likelihood of developing MS (refs. 2, 5); (4) abnormal immune responses to a variety… CONTINUE READING
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