Association of human, rat, and rabbit apolipoprotein E with beta-amyloid.

  title={Association of human, rat, and rabbit apolipoprotein E with beta-amyloid.},
  author={Mary Jo Ladu and John R Lukens and Catherine A. Reardon and G. S. Getz},
  journal={Journal of neuroscience research},
  volume={49 1},
In humans, apolipoprotein E (apoE) has three major isoforms, E2 (Cys112, Cys158), E3 (Cys112, Arg158), and E4 (Arg112, Arg158). While epsilon4 is a genetic risk factor for Alzheimer's disease (AD), epsilon2 may protect against late-onset AD. Using native preparations of apoE from conditioned tissue culture media or plasma lipoproteins, we have previously shown that when equivalent amounts of apoE3 or E4 were incubated with beta-amyloid (A beta), apoE3 formed 20 times as much SDS-stable complex… CONTINUE READING
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