Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state.

@article{Humberstone1998AssociationOH,
  title={Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state.},
  author={Andrew J. Humberstone and Christopher J. H. Porter and Glenn Anthony Edwards and William Neil Charman},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 8},
  pages={936-42}
}
The oral bioavailability of halofantrine (Hf), a highly lipophilic phenanthrenemethanol antimalarial, is significantly enhanced when ingested with food. Although food enhances the absorption of Hf, it also alters the intrinsic pharmacokinetics of Hf as the observed postprandial absolute bioavailability was greater than 100% (Humberstone et al., J. Pharm. Sci. 1996, 85, 525-529). In this study, the association of Hf with plasma lipoproteins and the effect of postprandial lipoproteins on the… CONTINUE READING

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