Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

@article{Stratton2000AssociationOG,
  title={Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study},
  author={Irene M. Stratton and Amanda I. Adler and H. Andrew W. Neil and David R. Matthews and Susan E Manley and Carole A. Cull and D. R. Hadden and Robert C. Turner and Rury R. Holman},
  journal={BMJ : British Medical Journal},
  year={2000},
  volume={321},
  pages={405 - 412}
}
OBJECTIVE To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes. [...] Key MethodDESIGN Prospective observational study. SETTING 23 hospital based clinics in England, Scotland, and Northern Ireland. Expand

Paper Mentions

Interventional Clinical Trial
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ConditionsDiabetes type2, Obesity
InterventionDevice, Other
Interventional Clinical Trial
There are numerous possible reasons why it could be speculated that HbA1c variability may affect complication risk. Of interest are the concepts that both laboratory and clinic… Expand
ConditionsDiabetes Mellitus Type 2
InterventionDrug
Interventional Clinical Trial
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ConditionsDiabetes Mellitus
InterventionBehavioral
Interventional Clinical Trial
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ConditionsType2 Diabetes Mellitus
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TLDR
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Microvascular Disease and Risk of Cardiovascular Events and Death From Intensive Treatment in Type 2 Diabetes: The ACCORDION Study.
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Symptomatic, severe hypoglycaemia was associated with an increased risk of death within each study arm, however, among participants who experienced at least one episode of hypglycaemia, the risk ofdeath was lower in such participants in the intensive arm than in the standard arm. Expand
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Glycated haemoglobin variability was associated with increased incidence of nephropathy, while mean glycated Haemoglobin emerged as independent risk factor for the development of retinopathy and peripheral neuropathy. Expand
The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis
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Chronic hyperglycemia is associated with an increased risk for cardiovascular outcomes and all-cause mortality among patients with type 2 diabetes, likely independently from other conventional risk factors. Expand
Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study
TLDR
Raised HbA(1c) could be an independent risk factor for stroke in people with and without diabetes, with relative risks similar to those previously reported for coronary heart disease. Expand
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In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure, with the lowest risk being in those with systolic blood pressure less than 120 mm Hg. Expand
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