Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

@article{Smith2010AssociationOG,
  title={Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.},
  author={Nicholas L. Smith and Janine F. Felix and Alanna C. Morrison and Serkalem Demissie and Nicole L. Glazer and Laura R. Loehr and L. Adrienne Cupples and Abbas Dehghan and Thomas Lumley and Wayne D. Rosamond and Wolfgang Lieb and Fernando Rivadeneira and Joshua C Bis and Aaron R Folsom and Emelia J Benjamin and Yurii S. Aulchenko and Talin Haritunians and David Couper and Joanne Murabito and Ying A Wang and Bruno Hch Stricker and John S. Gottdiener and Patricia Pat-Yue Chang and Thomas J. Wang and Kenneth M Rice and Albert Hofman and Susan R. Heckbert and Ervin R. Fox and Christopher J. O'Donnell and Andr{\'e} G. Uitterlinden and Jerome I Rotter and James T. Willerson and Daniel Levy and Cornelia M van Duijn and Bruce M. Psaty and Jacqueline C. M. Witteman and Eric Boerwinkle and Ramachandran S. Vasan},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 3},
  pages={256-66}
}
BACKGROUND Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the association of 2,478,304 single-nucleotide polymorphisms with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study. METHODS AND RESULTS Eligible… CONTINUE READING

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