Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.

@article{Levran2013AssociationOG,
  title={Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.},
  author={Orna Levran and Einat Peles and Matthew Randesi and Xu Shu and J{\"u}rg Ott and Pei-Hong Shen and Miriam Adelson and Mary Jeanne Kreek},
  journal={Pharmacogenomics},
  year={2013},
  volume={14 7},
  pages={755-68}
}
AIM The interindividual variability in the dose required for effective methadone maintenance treatment (MMT) for opioid addiction may be influenced in part by genetic variations in genes encoding pharmacodynamic factors of methadone. This study was conducted to identify some of these variants. MATERIALS & METHODS This study focused on 11 genes encoding components of the opioidergic (OPRM1, POMC and ARRB2), the dopaminergic (ANKK1 and DRD2) and the glutamatergic pathways (GRIN1 and GRIN2A), as… CONTINUE READING

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