Association of genetic variants at 8q24 with breast cancer risk.

  title={Association of genetic variants at 8q24 with breast cancer risk.},
  author={Olivia Fletcher and Nichola Johnson and Lorna Gibson and Ben Coupland and Agnes Fraser and Angela Leonard and Isabel M dos Santos Silva and Alan Ashworth and Richard S. Houlston and Julian Peto},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={17 3},
Recent whole genome association studies of prostate, breast, and colorectal cancer have identified susceptibility loci on 8q24. We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls. 1,267 (85%) of the cases had two primary breast cancers. Our analysis provides further… CONTINUE READING
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