Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.

@article{Wan2002AssociationOG,
  title={Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.},
  author={Junxiang Wan and Jinxiu Shi and Lijian Hui and Dan Wu and Xipeng Jin and Naiqing Zhao and Wei Huang and Zhao-lin Xia and Gengxi Hu},
  journal={Environmental Health Perspectives},
  year={2002},
  volume={110},
  pages={1213 - 1218}
}
Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lifestyle factors such as cigarette smoking and alcohol consumption were also explored. We studied 156… CONTINUE READING

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