Association of genes to genetically inherited diseases using data mining
@article{PerezIratxeta2002AssociationOG, title={Association of genes to genetically inherited diseases using data mining}, author={C. Perez-Iratxeta and P. Bork and M. Andrade}, journal={Nature Genetics}, year={2002}, volume={31}, pages={316-319} }
Although approximately one-quarter of the roughly 4,000 genetically inherited diseases currently recorded in respective databases (LocusLink, OMIM) are already linked to a region of the human genome, about 450 have no known associated gene. Finding disease-related genes requires laborious examination of hundreds of possible candidate genes (sometimes, these are not even annotated; see, for example, refs 3,4). The public availability of the human genome draft sequence has fostered new strategies… CONTINUE READING
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References
SHOWING 1-10 OF 15 REFERENCES
A Comparison of the Celera and Ensembl Predicted Gene Sets Reveals Little Overlap in Novel Genes
- Biology, Medicine
- Cell
- 2001
- 199
- PDF
Autosomal Recessive Hypercholesterolemia Caused by Mutations in a Putative LDL Receptor Adaptor Protein
- Biology, Medicine
- Science
- 2001
- 525
- PDF
Glutamate dehydrogenase deficiency in cerebellar degenerations: clinical, biochemical and molecular genetic aspects.
- Biology, Medicine
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
- 1993
- 43
- PDF
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
- Biology, Medicine
- Nature Genetics
- 2001
- 674
- PDF