Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves.

@article{An2014AssociationOG,
  title={Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves.},
  author={Sook Hee An and Kyung Eun Lee and Byung Chul Chang and Hye Sun Gwak},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2014},
  volume={39 3},
  pages={314-8}
}
WHAT IS KNOWN AND OBJECTIVE Pharmacogenetic studies of the genetic regulation of warfarin dose requirement have been reported, but few have been on the bleeding complications at therapeutic international normalized ratio (INR). This study aimed to evaluate the effect of gene polymorphisms of CYP2C9, VKORC1, thrombomodulin (THBD) and C-reactive protein (CRP) on the risk of bleeding complications of warfarin at therapeutic INR in Korean patients with mechanical cardiac valves. METHODS A… CONTINUE READING
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