Association of gastric and intestinal phenotypic marker expression of gastric carcinomas with tumor thymidylate synthase expression and response to postoperative chemotherapy with 5-fluorouracil

@article{Tajima2003AssociationOG,
  title={Association of gastric and intestinal phenotypic marker expression of gastric carcinomas with tumor thymidylate synthase expression and response to postoperative chemotherapy with 5-fluorouracil},
  author={Yusuke Tajima and Tadakazu Shimoda and Yukihiro Nakanishi and Noboru Yokoyama and Takayuki Tanaka and Kouji Shimizu and Toyohiko Saito and Masatoshi Kawamura and Mitsuo Kusano and Kazuhide Kumagai},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2003},
  volume={129},
  pages={683-690}
}
It is well known that both gastric and intestinal phenotypic markers are expressed in gastric carcinomas, irrespective of their histological type. In the present study, the associations among phenotypic marker expression of gastric carcinomas, tumor thymidylate synthase (TS) expression, and the chemotherapeutic response to 5-fluorouracil (5-FU) were examined. The gastric and intestinal phenotypic marker expression of the tumor was determined by the combination of the expression of human gastric… CONTINUE READING

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