• Corpus ID: 26041581

Association of free fatty acids with the insulin-resistant state but not with central obesity in individuals from Venezuela.

  title={Association of free fatty acids with the insulin-resistant state but not with central obesity in individuals from Venezuela.},
  author={Gilberto Campos and Virginia Fern{\'a}ndez and Erika Fern{\'a}ndez and Emperatriz Molero and Luz Marina Morales and Xiomara Raleigh and Lissette Connell and Elena Ryder},
  journal={Investigacion clinica},
  volume={51 1},
Individuals with insulin resistance (IR) usually have upper body obesity phenotype, often accompanied by an increase in plasma free fatty acids (FFA). Since the Venezuelan population has a high frequency of IR and central obesity, the purpose of this work was to determine FFA levels in 47 Venezuelan individuals, men and women, 24-58 years old, and analyze their relationship with central obesity and parameters of carbohydrate and lipid metabolism. Basal concentrations of TG, total cholesterol… 
FFA level in obese without DM Type -II verses Obese with DM Type-II were either normal or below normal so it was concluded that FFA level was not so much related with insulin r esistance in this study group.
Serum Free Fatty Acid (FFA) Level in Obese with DM Type-II
FFA level in obese without DM Type-II verses Obese with DM type-II were either normal or below normal so it was concluded that FFA level was not so much related with insulin resistance in this study group.
The role of the lipotoxicity in the pathogenesis of type 2 diabetes mellitus and obesity
This study focuses on the fatty acids metabolism, the increase in concentrations of which plays a significant role in the pathophysiological mechanisms associated with insulin resistance.
Determination of roc curves for the study of cut-off levels for waist circumference in pediatric population of three regions of venezuela assessed in the SENACREDH
Background. Highly active antiretroviral therapy in HIV-infected patients minimizes viral replication, restores immune status and thus decreases morbidity and mortality. Objective. Determine
Esteatosis hepática, grasa visceral y alteraciones metabólicas, en individuos con sobrepeso/obesidad aparentemente sanos.
Los resultados resaltan the importancia of investigar mas the presen-cia of esteatosis hepatica en los individuos con SP/OB, that the estimacion dela grasa visceral, para identificar sujetos con alto riesgo cardiometabolico.
Determinación de puntos de corte para la circunferencia de cintura a través de curvas ROC en población pediátrica de tres regiones de Venezuela evaluada en el SENACREDH
Background: In the context of the Second National Study on Human Growth and Development of the Bolivarian Republic of Venezuela (SENACREDH), for the first ti...


Free fatty acids-the link between obesity and insulin resistance.
  • G. Boden
  • Medicine
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2001
Evidence is presented that free fatty acids (FFA) are an important link between obesity and insulin resistance and have been shown to have an important contributing role in the pathogenesis of insulin resistance in human obesity.
[Prevalence of obesity and hyperinsulinemia: its association with serum lipid and lipoprotein concentrations in healthy individuals from Maracaibo, Venezuela].
A high percentage of men and women in this study showed obesity and this obesity, specially in men, was strongly associated with lipid profile alterations and high insulin concentrations both well known cardiovascular risk factors.
The importance of free fatty acids in the development of Type 2 diabetes
  • J. Wilding
  • Medicine
    Diabetic medicine : a journal of the British Diabetic Association
  • 2007
Recent study results suggest that peroxisome proliferator‐activated receptor (PPAR)γ agonists have an effect on the development of Type 2 diabetes, however, in light of concerns over the apparent increase in congestive heart failure with PPARγ agonist, their place in the prevention of Type 1 diabetes remains to be determined.
Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes.
In order to demonstrate the effect of family history (FH) coexisting with obesity in insulin resistance (IR) and secretion in subjects at risk for type 2 diabetes, fasting and 2 h post-glucose load
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
Evidence is discussed that FFA represent a crucial link between insulin resistance and β‐cell dysfunction and, as such, a reduction in elevated plasma FFA should be an important therapeutic target in obesity and type 2 diabetes.
Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle.
  • Jianping Ye
  • Biology, Medicine
    Endocrine, metabolic & immune disorders drug targets
  • 2007
A substantial support for the role of insulin in the early stages of FFA-associated insulin resistance is provided by the hypothesis of insulin's role in lipotoxicity, and prevention of increased beta-cell response to glucose may be a potential approach for early intervention of metabolic syndrome.
Point: visceral adiposity is causally related to insulin resistance.
Long-term longitudinal population-based studies of men and women in Gothenburg, Sweden, showed that the waist-to-hip ratio was a predictor of the future development of diabetes, myocardial infarction, angina pectoris, stroke, and death independent of BMI.
Relationships between glycaemic abnormalities, obesity and insulin resistance in nondiabetic Polynesians of New Caledonia
Despite a high prevalence of central obesity, as judged by high BMI and WHR, in Polynesians of New Caledonia, their high risk of diabetes may be more strongly related to a defect in insulin secretion capacity than to insulin resistance.
Relationship of Generalized and Regional Adiposity to Insulin Sensitivity in Men With NIDDM
It is concluded that NIDDM patients do not have excess intraperitoneal fat, but that their fat distribution favors more truncal and less peripheral subcutaneousFat, and for each level of total and regional adiposity, NIDs patients have a heightened state of insulin resistance.
Thematic review series: Patient-Oriented Research. Free fatty acid metabolism in human obesity Published, JLR Papers in Press, May 10, 2006.
Obesity-related abnormalities in subcutaneous lipolysis could be more important than those in viscerallipolysis as a cause of peripheral insulin resistance and the regulation of FFA availability will help to discover new approaches to treat FFA-induced abnormalities in obesity.