Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis

@article{DerakhshandeRishehri2014AssociationOF,
  title={Association of foods enriched in conjugated linoleic acid (CLA) and CLA supplements with lipid profile in human studies: a systematic review and meta-analysis},
  author={Seyede-Masome Derakhshande-Rishehri and Marjan Mansourian and Roya Kelishadi and Motahar Heidari-Beni},
  journal={Public Health Nutrition},
  year={2014},
  volume={18},
  pages={2041 - 2054}
}
Abstract Objective The present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies. Design Systematic review and meta-analysis. Setting Search process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid… 
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Association of conjugated linoleic acid consumption and liver enzymes in human studies: A systematic review and meta-analysis of randomized controlled clinical trials.
The effects of conjugated linoleic acid (CLA) on metabolic syndrome patients: A systematic review and meta-analysis
The links between supplementary tannin levels and conjugated linoleic acid (CLA) formation in ruminants: A systematic review and meta-analysis
TLDR
The in vivo method was more suitable for the direct observation of fatty acid transformation than the in vitro method, as indicated by the statistical meta-analysis results regarding animal aspects.
Comparison of Fatty Acid Composition in Selected Dietary Supplements Containing Conjugated Linoleic Acid
TLDR
It was found that content of CLA in selected dietary supplements ranged between 282 and 528 mg by weight of a single capsule, and the content of bioactive ingredients found in three of the four product supplements assessed was lower than was claimed by the manufacturer.
Milk Fatty Acid Profiles in Different Animal Species: Focus on the Potential Effect of Selected PUFAs on Metabolism and Brain Functions
TLDR
How animal feeding—the main way to modify milk fat composition—may have a potential impact on human health, and how rearing and feeding systems strongly affect milk quality within the same animal species are presented.
Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia.
Co-administration of conjugated linoleic acid and rosiglitazone increases atherogenic co-efficient and alters isoprenaline-induced vasodilatation in rats fed high fat diet.
TLDR
The findings illustrate that the combination of CLA and rosiglitazone precede the atherogenic state with impaired endothelium-independent vasodilatation before the onset of HFD-induced insulin resistance.
Total conjugated linoleic acid content of ruminant milk: The world status insights.
Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel
TLDR
The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
Biotechnological Production of Conjugated Fatty Acids With Biological Properties
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References

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TLDR
It is suggested that supplementation with CLA may reduce the proportion of body fat in humans and that CLA affects fatty acid metabolism.
Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men.
TLDR
It is suggested that a 10-fold CLA enrichment of butter fat does not induce beneficial metabolic effects in overweight or obese men.
Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.
TLDR
This study shows that CLA supplementation for 24 mo in healthy, overweight adults was well tolerated and confirms also that CLA decreases BFM in overweight humans, and may help maintain initial reductions in BFM and weight in the long term.
Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat.
Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components.
TLDR
The supplementation of milk with 3 g CLA over 12 weeks results in a significant reduction of fat mass in overweight but not in obese subjects, and CLA supplementation was not associated with any adverse effects or biological changes.
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TLDR
Contrary to findings from some animal studies, CLA does not seem to offer health benefits, in the short term, regarding the prevention of atherosclerosis in humans.
Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study.
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TLDR
Data indicate that supplementation with 2.1 g of CLA daily for 45 d increased its levels in blood but had no effect on body composition or the lipidemic profile of nonobese women.
Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans.
TLDR
Long-term supplementation with CLA-FFA or CLA-triacylglycerol reduces BFM in healthy overweight adults, and adverse events did not differ significantly between groups.
Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects.
TLDR
The present results suggest that a 98 d supplementation diet with a 50 : 50 mixture of the two CLA isomers cis-9, trans-11 and trans-10, cis-12 in a dairy product was unable to alter body composition, although a significant increase in the RMR has been induced.
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