Association of fluconazole pharmacodynamics with mortality in patients with candidemia.

@article{Baddley2008AssociationOF,
  title={Association of fluconazole pharmacodynamics with mortality in patients with candidemia.},
  author={John W. Baddley and Mukesh Patel and Sujata M. Bhavnani and Stephen A. Moser and David R Andes},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 9},
  pages={3022-8}
}
Recent studies of nonneutropenic patients with candidemia or candidiasis suggest that fluconazole pharmacodynamic parameters correlate with clinical outcomes; however, additional data of correlation to mortality in patients with candidemia would be valuable. We assessed the impact of MICs for Candida, fluconazole pharmacodynamics, and patient characteristics on all-cause mortality with use of a prospective cohort of 96 hospitalized patients with candidemia. Among 84 patients for whom Candida… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Antifungal pharmacodynamics: Latin America's perspective.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases • 2017

Differential association of fluconazole dose and dose/MIC ratio with mortality in patients with Candida albicans and non-albicans bloodstream infection.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases • 2015
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Invasive candidiasis.

Infectious disease clinics of North America • 2006

Pharmacokinetics and pharmacodynamics of antifungals.

Infectious disease clinics of North America • 2006

Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2006

Similar Papers

Loading similar papers…