Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?

@article{Ziyab2014AssociationOF,
  title={Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier?},
  author={Ali H Ziyab and W. Karmaus and Hongmei Zhang and John W Holloway and Susan E Steck and Susan L. Ewart and Syed Hasan Arshad},
  journal={International archives of allergy and immunology},
  year={2014},
  volume={164 4},
  pages={308-18}
}
BACKGROUND Associations of variants of the filaggrin gene, i.e. FLG with asthma and rhinitis have been shown to be modulated by eczema status. However, it is unknown whether allergic sensitization status modifies this association. The aim of this study was to determine whether FLG variants need eczema and/or allergic sensitization as a necessary component to execute adverse effects on coexisting and subsequent asthma and rhinitis. METHODS In the Isle of Wight birth cohort, repeated… CONTINUE READING