Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control.

Abstract

Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.

DOI: 10.1016/j.schres.2016.03.014

Cite this paper

@article{Antonucci2016AssociationOF, title={Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control.}, author={Linda Antonella Antonucci and Paolo Taurisano and Leonardo Fazio and Barbara Gelao and Raffaella Romano and Tiziana Quarto and Annamaria Porcelli and Marina Mancini and Annabella Di Giorgio and Grazia Caforio and Giulio Pergola and Teresa Popolizio and Alessandro Bertolino and Giuseppe Blasi}, journal={Schizophrenia research}, year={2016}, volume={173 1-2}, pages={23-9} }