Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis.

@article{Shieh2007AssociationOE,
  title={Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis.},
  author={Tzong-Ming Shieh and Shu-Chun Lin and Chung-Ji Liu and Shu-Shin Chang and Ti-Hsuan Ku and Kuo-Wei Chang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 15 Pt 1},
  pages={
          4378-85
        }
}
PURPOSE Areca nut use is the major cause of oral squamous cell carcinoma (OSCC) in Southern Asians. Areca nut contains a high level of free copper ions. Lysyl oxidase (LOX) is a copper-activated enzyme critical for extracellular matrix organization. Contradictory evidence has been put forward to suggest that LOX may be either an oncogenic or a suppressive element. This study investigated the oncogenic significance of LOX in areca-associated OSCC. EXPERIMENTAL DESIGN The expression assays and… CONTINUE READING
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