Association of exonic variants of Klotho with metabolic syndrome in Asian Indians.

  title={Association of exonic variants of Klotho with metabolic syndrome in Asian Indians.},
  author={Vijaya Majumdar and Rita Christopher},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={412 11-12},
BACKGROUND Klotho, an anti-aging gene, is a functional candidate for metabolic syndrome. We conducted a cross-sectional study to evaluate the association of the genetic variants of Klotho with metabolic syndrome and surrogates of insulin resistance in Asian Indians. METHODS We recruited 428 clinically normal subjects for the study. Genotyping was done by polymerase chain reaction and restriction fragment length polymorphism. RESULTS Significant and borderline associations of the KL-VS (OR… CONTINUE READING


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