Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.

@article{Capuron2003AssociationOE,
  title={Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.},
  author={Lucile Capuron and Charles L. Raison and Dominique L. Musselman and David H. Lawson and Charles B. Nemeroff and Andrew H. Ivan Miller},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 7},
  pages={
          1342-5
        }
}
OBJECTIVE The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment. METHOD Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha… CONTINUE READING

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