Association of estrogens with human plasma lipoproteins: studies using estradiol-17beta and its hydrophobic derivative.

@article{Tang1997AssociationOE,
  title={Association of estrogens with human plasma lipoproteins: studies using estradiol-17beta and its hydrophobic derivative.},
  author={M. Tang and W. Abplanalp and M. Subbiah},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={129 4},
  pages={
          447-52
        }
}
Estrogen replacement therapy is widely used to combat symptoms of menopause, but factors influencing the transport of estrogen in plasma and its cellular uptake have been explored only to a limited extent. In this study, labeled estradiol-17beta (E2) was compared with its hydrophobic derivative (estradiol-3,17-diacetate, E2AA) in terms of (1) distribution within various lipoproteins and lipoprotein-free fractions of human plasma by ultracentrifugation and (2) uptake by human endothelial cells… Expand
Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particles.
17beta-estradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation.
Quantitative determination of estradiol fatty acid esters in lipoprotein fractions in human blood.
Estradiol as an antioxidant: incompatible with its physiological concentrations and function.
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