Association of elevated IGF-I levels with increased retinopathy in late-onset diabetes.

@article{Dills1991AssociationOE,
  title={Association of elevated IGF-I levels with increased retinopathy in late-onset diabetes.},
  author={Diana G Dills and Scot E Moss and Ronald E Klein and Barbara E. Klein},
  journal={Diabetes},
  year={1991},
  volume={40 12},
  pages={1725-30}
}
Insulinlike growth factor I (IGF-I) has been suggested to play a role in the pathogenesis of proliferative diabetic retinopathy (PDR). We determined IGF-I levels in subjects in a large population-based study of 928 people with diabetes diagnosed at 30 yr of age or older. PDR was found in 15.7% of the insulin-using group (n = 517) and in 2.8% of those not using insulin (n = 397). The mean serum level of IGF-I was 208 micrograms/L in individuals using insulin and 222 micrograms/L in those not… CONTINUE READING

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