Association of ebola virus matrix protein VP40 with microtubules.

  title={Association of ebola virus matrix protein VP40 with microtubules.},
  author={Gordon T Ruthel and Gretchen L. Demmin and George H Kallstrom and Melodi P. Javid and Shirin S Badie and Amy B. Will and Timothy Nelle and Rowena D Schokman and Tam L Nguyen and John H. Carra and Sina Bavari and Mohammed Aman},
  journal={Journal of virology},
  volume={79 8},
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for many viruses. A variety of viral proteins have been identified that interact with microtubules, either directly or via a microtubule-associated motor protein. Here, we report that Ebola virus associates with microtubules via the matrix protein VP40. When transfected into mammalian cells, a fraction of… CONTINUE READING
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