Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia.

@article{McKeigue1993AssociationOE,
  title={Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia.},
  author={Paul McKeigue and Jane E. Ferrie and Tracey Pierpoint and Michael Marmot},
  journal={Circulation},
  year={1993},
  volume={87 1},
  pages={152-61}
}
BACKGROUND Rates of coronary heart disease are higher in South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas than in other ethnic groups. We tested the hypothesis that this excess risk results from metabolic disturbances associated with insulin resistance. METHODS AND RESULTS There were 1,421 South Asian men and 1,515 European men aged 40-69 years in London examined in the Southall Study. Prevalence of ischemic ECG abnormalities was higher in South Asians than in Europeans… CONTINUE READING
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