Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in Australians deployed abroad

  title={Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in Australians deployed abroad},
  author={T W Lee and L Russell and Min Deng and Peter R. Gibson},
  journal={Internal Medicine Journal},
The risks are unknown for developing chronic gastrointestinal illness when personnel are relocated short term to other countries and when taking antibiotic prophylaxis in areas where malaria is endemic. 
Antibiotic use and subsequent development of functional gastrointestinal disorders: effect of symptom‐reporting and consultation behavior
  • T. P. Bidmead, A. Ford
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2016
A nested case–control study that provides important evidence of an association between antibiotic use and the subsequent development of FGIDs, which has biological plausibility, and serves as yet another reason for judicious use of these drugs.
Isotretinoin for acne vulgaris - an update on adverse effects and laboratory monitoring.
An update on the evidence surrounding the adverse effects of isotretinoin is provided, and practical strategies to prevent and manage these adverse effects are discussed.
The use of isotretinoin for acne – an update on optimal dosing, surveillance, and adverse effects
Oral isotretinoin is the unique treatment for cure or prolonged remission for moderate and severe acne, preventing psychosocial impact and scars, and no other therapeutic option, even topicals combined to oral antibiotics accomplish same results.
Treating acne with the tetracycline class of antibiotics: A review
It is vital that the clinician understand the pros and cons of each tetracycline agent so as to optimally serve the acne population.
Sarecycline treatment for acne vulgaris: Rationale for weight‐based dosing and limited impact of food intake on clinical efficacy
Weight‐based dosing protocols and the impact of food intake, including high‐fat meals, on the absorption, and clinical efficacy of sarecycline, a novel oral narrow‐spectrum third‐generation tetracycline‐class antibiotic approved by the Food and Drug Administration for acne vulgaris treatment are investigated.
Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case-Control Study in the UK Clinical Practice Research Datalink.
There was no association between UC or CD and overall prior use of antibiotics, though prior useof metronidazole and quinolones was associated with a slightly increased risk of CD.
Sarecycline: A Review of Preclinical and Clinical Evidence
The narrower spectrum of antibacterial activity of sarecycline, which specifically targets C. acnes and some Gram-positive bacteria with little or no activity against Gram-negative bacteria, suggests not only the potential for reduced emergence of antibiotic-resistant bacterial strains but also less disruption of the human gut microflora.
Prevention of Malaria in Travelers: Bite Avoidance and Chemoprophylactic Measures
Atovaquone-proguanil is highly effective in preventing Plasmodium falciparum malaria, is well-tolerated, and is active against both liver and blood stages, which decreases the length of time required for post-travel prophylaxis, and alternative agents include doxycycline and mefloquine.
Mechanisms of Bacterial Resistance
In 1900, the three leading causes of death were pneumonia, tuberculosis, and diarrhea with enteritis. Today, due to the control of infectious diseases over the last century, the leading causes of


Systematic review and meta‐analysis: the incidence and prognosis of post‐infectious irritable bowel syndrome
A large number of studies suggest that post‐infectious irritable bowel syndrome is common, but symptoms gradually improve, and the prognosis is generally good.
Influence of oral doxycycline therapy on the diversity and antibiotic susceptibility of human intestinal bifidobacterial population
Aim:  To evaluate the influence of doxycycline therapy on the composition and antibiotic susceptibility of intestinal bifidobacteria.
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
The role of the gut microbiota in patho‐physiology of irritable bowel syndrome (IBS) is suggested by several studies. However, standard cultural and molecular methods used to date have not revealed
Use of broad-spectrum antibiotics and the development of irritable bowel syndrome.
Use of broad-spectrum antibiotics--particularly macrolides or tetracyclines--may be associated with IBS development, and this study is the first to know of no other study that has associated these antibiotics with Ibs development.
Prophylactic doxycycline for travelers' diarrhea in Thailand. Further supportive evidence of Aeromonas hydrophila as an enteric pathogen.
Doxycycline prophylaxis of travelers' diarrhea in this geographic area, though not shown to be significantly protective, further supports the role of A. hydrophila as an enteric pathogen.
Post-Infectious Irritable Bowel Syndrome, an Inflammation-Immunological Model with Relevance for Other IBS and Functional Dyspepsia
  • K. Gwee
  • Medicine
    Journal of neurogastroenterology and motility
  • 2010
This review presents studies that support an inflammation-immunological model for the pathogenesis of post-infectious irritable bowel syndrome (IBS), and highlights recent studies that support a
Potential Association Between the Oral Tetracycline Class of Antimicrobials Used to Treat Acne and Inflammatory Bowel Disease
Tetracycline class antibiotics, and particularly doxycycline use may be associated with the development of IBD, particularly CD.
Prevention of malaria in long-term travelers.
Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease.
The results are compatible with the hypothesis that infectious agents causing an episode of infectious gastroenteritis could play a role in the initiation and/or exacerbation of IBD.
Infectious gastroenteritis and risk of developing inflammatory bowel disease.
Data support theories that the initiation of IBD is a multifactorial process that might include the disruption of normal gut homeostatic mechanisms.