Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients.

@article{Ijichi2012AssociationOD,
  title={Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients.},
  author={Nobuhiro Ijichi and Takashi Shigekawa and Kazuhiro Ikeda and Kuniko Horie-Inoue and Chikako Shimizu and Shigehira Saji and Kenjiro Aogi and Hitoshi Tsuda and Akihiko Osaki and Toshiaki Saeki and Satoshi Inoue},
  journal={Hormones & cancer},
  year={2012},
  volume={3 4},
  pages={147-59}
}
Breast cancer is primarily a hormone-dependent tumor that can be regulated by the status of the steroid hormones estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as a pioneer factor of the estrogen receptor (ER) in breast cancer. In the present study, we demonstrate that FOXA1 mRNA was upregulated by estrogen and that estrogen receptor-α (ERα) recruitment to ER-binding sites in the vicinity of the FOXA1 gene was… CONTINUE READING
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