Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.

  title={Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.},
  author={N. Volkow and L. Chang and G. Wang and J. Fowler and M. Leonido-Yee and D. Franceschi and M. Sedler and S. Gatley and R. Hitzemann and Y. Ding and J. Logan and C. Wong and E. Miller},
  journal={The American journal of psychiatry},
  volume={158 3},
  • N. Volkow, L. Chang, +10 authors E. Miller
  • Published 2001
  • Psychology, Medicine
  • The American journal of psychiatry
  • OBJECTIVE Methamphetamine is a popular and highly addictive drug of abuse that has raised concerns because it has been shown in laboratory animals to be neurotoxic to dopamine terminals. The authors evaluated if similar changes occur in humans and assessed if they were functionally significant. METHOD Positron emission tomography scans following administration of [(11)C]d-threo-methylphenidate (a dopamine transporter ligand) measured dopamine transporter levels (a marker of dopamine cell… CONTINUE READING
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