Association of distinctive Epstein-Barr virus variants with gastric carcinoma in Guangzhou, southern China.

@article{Chen2010AssociationOD,
  title={Association of distinctive Epstein-Barr virus variants with gastric carcinoma in Guangzhou, southern China.},
  author={Jian-ning Chen and Yun-gang Ding and Zhiying Feng and Hai-gang Li and Dan He and Hong Du and Bin Wu and Chun-kui Shao},
  journal={Journal of medical virology},
  year={2010},
  volume={82 4},
  pages={658-67}
}
To investigate the clinicopathologic features, Epstein-Barr virus (EBV) latency pattern and genome polymorphism of EBV-associated gastric carcinoma (EBVaGC) in Guangzhou, an endemic area of nasopharyngeal carcinoma (NPC), an in situ hybridization assay of EBV-encoded small RNA-1 (EBER-1) was used to identify the presence of EBV in 676 consecutive gastric carcinoma cases. EBV-encoded proteins EBNA1, EBNA2, LMP1, and ZEBRA were detected by immunohistochemistry. EBV genome polymorphism was also… CONTINUE READING

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