Association of depressed cardiac gp130-mediated antiapoptotic pathways with stimulated cardiomyocyte apoptosis in hypertensive patients with heart failure.

@article{Gonzlez2007AssociationOD,
  title={Association of depressed cardiac gp130-mediated antiapoptotic pathways with stimulated cardiomyocyte apoptosis in hypertensive patients with heart failure.},
  author={Arantxa Gonz{\'a}lez and Susana Ravassa and I{\~n}igo Loperena and Bego{\~n}a Soler L{\'o}pez and J William Beaumont and Ram{\'o}n Querejeta and Mariano Larman and J M Olivares D{\'i}ez},
  journal={Journal of hypertension},
  year={2007},
  volume={25 10},
  pages={2148-57}
}
OBJECTIVE To investigate whether the glycoprotein (gp130)-mediated survival pathway, which protects cardiomyocytes from apoptosis, is depressed in left ventricular hypertrophy hypertensive patients with chronic heart failure. METHODS Transvenous endomyocardial biopsies were obtained in 52 hypertensive patients with left ventricular hypertrophy: 28 without heart failure and 24 with heart failure. gp130 and gp130-dependent antiapoptotic pathways p42/44 mitogen-activated protein kinase (MAPK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

gp130-mediated pathway and heart failure.

Future cardiology • 2008
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…