Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice.

Abstract

A "feedback suppressor T cell" highly dependent on signals from Ly 1 T helper cells for activation is described. The signal from the Ly 1 cell binds to Fc-like receptors on macrophage membranes. The feedback suppressor cell expresses all three Ly antigens as well as the Qa 1 antigen on its surface, is very sensitive to low doses of cyclophosphamide, disappears relatively rapidly after adult thymectomy, and cannot be demonstrated in NZB mice 6 weeks or older.

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@article{Gershon1978AssociationOD, title={Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice.}, author={Richard K. Gershon and Diane D. Eardley and K F Naidorf and Harvey Cantor}, journal={Arthritis and rheumatism}, year={1978}, volume={21 5 Suppl}, pages={S180-4} }