Association of decreased mitochondrial DNA content with ovarian cancer progression

@article{Wang2006AssociationOD,
  title={Association of decreased mitochondrial DNA content with ovarian cancer progression},
  author={Yonghui Wang and Vincent Wing Sun Liu and Wei Chen Xue and A. N. Y. Cheung and Hextan Y. S. Ngan},
  journal={British Journal of Cancer},
  year={2006},
  volume={95},
  pages={1087 - 1091}
}
Mitochondrial DNA (mtDNA) content in ovarian carcinomas was assessed by quantitative PCR. Results show that mtDNA content in tumour cell was significantly higher than that in normal ovary. Change in mtDNA content was not related with patients' age or tumour stages. However, the average mtDNA copy number in pathological low-grade tumours was over two-fold higher than that in high-grade carcinomas (P=0.012). Moreover, type I carcinomas also had a significantly higher mtDNA copy number than in… CONTINUE READING