Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.

@article{Majumdar2008AssociationOC,
  title={Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia.},
  author={Sunipa Majumdar and Bama Charan Mondal and Moloy K Ghosh and Sarmistha Dey and Ashis K. Mukhopadhyay and Sarmila Chandra and Uma B. Dasgupta},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={2008},
  volume={17 2},
  pages={125-32}
}
The objective of the paper was to study the association of polymorphisms of phases I and II xenobiotic metabolizing enzyme genes cytochrome P450 (CYP-4501A1*2A, *2B, *2C and *4 alleles, CYP-4502D6*4 allele), glutathione-S-transferase (GSTM1 and GSTT1 null genotypes) and N-acetyl transferase 2 (NAT2*6B and *7A alleles) with the incidence of acute myeloid leukemia (AML) in an eastern Indian population. Polymerase chain reaction and restriction fragment length polymorphism of genomic DNA from… CONTINUE READING