Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19

Abstract

Cyclophosphamide (CP), a widely used cytostatic, is metabolized by polymorphic drug metabolizing enzymes particularly cytochrome P450 (CYP) enzymes. Its side effects and clinical efficacy exhibit a broad interindividual variability, which might be due to differences in pharmacokinetics. CP-kinetics were determined in 60 patients using a global and a… (More)
DOI: 10.1038/sj.tpj.6500330

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