Association of cyclin D1 genotype with breast cancer risk and survival.

  title={Association of cyclin D1 genotype with breast cancer risk and survival.},
  author={Xiao-Ou Shu and Derek B Moore and Qiuyin Cai and Jiarong Cheng and Wanqing Wen and Larry Pierce and Hui Cai and Yu-tang Gao and Wei Zheng},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={14 1},
Cyclin D1 (CCND1) is a key cell cycle regulatory protein that governs cell cycle progression from the G(1) to S phase. A common polymorphism (A870G) in exon 4 of the CCND1 gene produces an alternate transcript (transcript-b) that preferentially encodes a protein with enhanced cell transformation activity and possible prolonged half-life. We evaluated the association of CCND1 A870G polymorphism with breast cancer risk and survival in 1,130 breast cancer cases and 1,196 controls who participated… CONTINUE READING
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Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women

  • TJ Key, PN Appleby, GK Reeves
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