Association of cyclin A and cdk2 with SV40 DNA in replication initiation complexes is cell cycle dependent

@article{Cannella1997AssociationOC,
  title={Association of cyclin A and cdk2 with SV40 DNA in replication initiation complexes is cell cycle dependent},
  author={Dominique Cannella and James M Roberts and Rati Fotedar},
  journal={Chromosoma},
  year={1997},
  volume={105},
  pages={349-359}
}
The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (CDK) in association with cyclins. In mammalian cells the timing of activation of cyclin A-associated kinase activity coincides with the onset of DNA synthesis in S-phase. Using in vitro replication of SV40 origin-containing DNA as a model system, we have analyzed… CONTINUE READING