Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.

@article{Poon2008AssociationOC,
  title={Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.},
  author={Audrey H. Poon and Kelan Tantisira and Augusto A Litonjua and Ross Lazarus and Jingsong Xu and Jessica A. Lasky-Su and J. J. G. Lima and Charles G. Irvin and John P. Hanrahan and Christoph Lange and Scott T. Weiss},
  journal={Pharmacogenetics and genomics},
  year={2008},
  volume={18 5},
  pages={373-82}
}
OBJECTIVE Corticotropin-releasing hormone receptor (CRHR)-2 participates in smooth muscle relaxation response and may influence acute airway bronchodilator response to short-acting beta2-agonist treatment of asthma. We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma. METHODS We investigated 28 single nucleotide polymorphisms in CRHR2 for associations with acute bronchodilator response to albuterol in 607 Caucasian asthmatic patients… CONTINUE READING