Association of complement factor H Y402H gene polymorphism with Alzheimer's disease.

  title={Association of complement factor H Y402H gene polymorphism with Alzheimer's disease.},
  author={Madeleine Zetterberg and Sara Landgren and Malin E. Andersson and Mona Seibt Palm{\'e}r and Deborah Ruth Gustafson and Ingmar Skoog and Lennart Minthon and Dag Steinar Thelle and Anders Wallin and Nenad Bogdanovi{\'c} and Niels Andreasen and K Blennow and Henrik Zetterberg},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={147B 6},
Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several epidemiological and biochemical features. The present study aimed to assess the possible influence of the AMD-associated complement factor H (CFH) Y402H (1277T > C) polymorphism on the risk of AD. Caucasian subjects (n = 800) meeting the criteria for probable (n = 717) or definite (n = 83) AD and Caucasian non-demented controls (n = 1265) were included in this multi-center case-control study, in which genotype and… CONTINUE READING


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