Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

@article{Pawlikowska2009AssociationOC,
  title={Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.},
  author={Ludmila Pawlikowska and Donglei Hu and Scott Huntsman and Andrew Goh Lee Sung and Catherine Chu and Justin Chen and Alexander Holland Joyner and Nicholas J. Schork and Wen Chi Hsueh and Alex P. Reiner and Bruce M. Psaty and Gil Atzmon and Nir Barzilai and Steve Cummings and WarrenS. Browner and Pui-Yan Kwok and Elad Ziv},
  journal={Aging cell},
  year={2009},
  volume={8 4},
  pages={
          460-72
        }
}
The insulin/IGF1 signaling pathways affect lifespan in several model organisms, including worms, flies and mice. To investigate whether common genetic variation in this pathway influences lifespan in humans, we genotyped 291 common variants in 30 genes encoding proteins in the insulin/IGF1 signaling pathway in a cohort of elderly Caucasian women selected from the Study of Osteoporotic Fractures (SOF). The cohort included 293 long-lived cases (lifespan > or = 92 years (y), mean +/- standard… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 142 CITATIONS

Similar Papers

Loading similar papers…