Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.

@article{Liu2007AssociationOC,
  title={Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China.},
  author={Ran Liu and Li-hong Yin and Yue-pu Pu},
  journal={Chinese medical journal},
  year={2007},
  volume={120 20},
  pages={1797-802}
}
BACKGROUND Cytochrome P450 2E1 (CYP2E1) has an important role in the metabolic activation of precarcinogens such as N-nitrosoamines and other low relative molecular mass, organic compounds. This study examined whether CYP2E1 RsaI and DraI polymorphism are associated with susceptibility to esophageal squamous cell carcinoma and the correlation between the genotypes and expression levels of CYP2E1 mRNA. METHODS Seventy-seven patients with newly diagnosed, untreated esophageal squamous cell… CONTINUE READING
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