Association of codon 72 polymorphism of p53 with lower prostate cancer risk.

@article{Henner2001AssociationOC,
  title={Association of codon 72 polymorphism of p53 with lower prostate cancer risk.},
  author={William David Henner and A J Evans and K M Hough and Emily L. Harris and Bruce A. Lowe and Tomasz M Beer},
  journal={The Prostate},
  year={2001},
  volume={49 4},
  pages={
          263-6
        }
}
BACKGROUND A common germline polymorphism of p53 produces a protein with an Arg to Pro change at codon 72. This Pro variant has altered biochemical properties suggesting altered cancer susceptibility. METHODS A case control study with 115 men with prostate cancer and 181 community control male subjects was conducted. Demographics, family history of cancer, and blood were obtained. Codon 72 genotypes were determined using PCR. RESULTS The Pro/Pro genotype was associated with a markedly lower… CONTINUE READING

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  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2004
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