Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.

@article{Cordell2010AssociationOC,
  title={Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.},
  author={Paul A. Cordell and Benjamin T. Kile and Kristina F. Standeven and Emma C. Josefsson and Richard J. Pease and Peter J Grant},
  journal={Blood},
  year={2010},
  volume={115 13},
  pages={
          2674-81
        }
}
Factor XIII-A (FXIII-A) is present in the cytosol of platelets, megakaryocytes, monocytes, osteoblasts, and macrophages and may be released from cells by a nonclassical pathway. We observed that plasma FXIII-A levels were unchanged in thrombocytopenic mice (Bcl-x(Plt20/Plt20) and Mpl(-/-)), which implicates nonclassical secretion from nucleated cells as the source of plasma FXIII-A. We, therefore, examined the intracellular targeting of FXIII-A in the THP-1 (monocyte/macrophage) cell line and… 
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Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation
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The data suggest that monocyte-derived FXIII-A externalized in response to stimuli participates in thrombus stabilization, via a transglutaminase-dependent mechanism.
Factor XIII and inflammatory cells.
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A
TLDR
This work suggests that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor, suggesting that a limited population of niches exists that support FX III-A-releasing cells.
Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.
TLDR
The role of FXIII in maintaining pregnancy, its contribution to the wound healing process, and its proangiogenic function are reviewed in details.
Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
TLDR
Three pools ofFXIII-A exist within the circulation: plasma where it circulates in complex with the inhibitory FXIII-B subunits, and the cellular form encased within platelets and monocytes/macrophages, which are examined to support their function in haemostasis and wound healing.
Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes
TLDR
The loss of cellular FXIII-A may impact migration and phagocytosis, and hence limit pathogen eradication in UC.
Functional factor XIII-A is exposed on the stimulated platelet surface.
TLDR
Data show a functional role for platelet FXIII-A through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking α2AP to fibrin.
Factor XIII-A transglutaminase acts as a switch between preadipocyte proliferation and differentiation.
TLDR
FXIII-A serves as a preadipocyte-bound proliferation/differentiation switch that mediates effects of hepatocyte-produced circulating pFN, which acts as a negative regulator of adipogenesis.
Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions.
TLDR
There are good rationales for evaluating the therapeutic potential of FXIII in diseases in which tissue repair is dysregulated or perturbed, including systemic sclerosis, invasive bacterial infections, and tissue repair, for instance healing of venous leg ulcers or myocardial injuries.
Substrates of Factor XIII-A: roles in thrombosis and wound healing.
TLDR
The present review discusses the substrates of FXIIIa (activated FXIII) involved in thrombosis and wound healing with a particular focus on the influence of plasma FX IIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown.
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